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Learning Portal, an online catalogue of our training and education initiatives,
provides you an easy way to explore different programmes that would best fit your learning needs and preferences.

Non-viral Reprogrammed Mesenchymal Stem Cells in Oncology

Non-viral Reprogrammed Mesenchymal Stem Cells in Oncology

There is currently over a thousand clinical trials using Mesenchymal Stem Cells (MSC) for various indications. While MSCs demonstrate an exceptional safety profile, it is increasingly clear that MSC therapies fail to progress beyond pre-clinical studies and are unsuccessful in late-stage clinical trials. These limitations are thought to be due to technical and biological issues […]
Enhancing the Efficacy of Dendritic Cells for Immunotherapy

Enhancing the Efficacy of Dendritic Cells for Immunotherapy

Epstein-Barr virus (EBV) is associated with many cancers, including nasopharyngeal carcinoma (NPC). Induction of an immune response against EBV could potentially be employed for elimination of NPC and other EBV-associated cancers. Dendritic cells (DC) are potent induces of immune responses, and are being tested for cancer immunotherapy. Prof Schwarz and his team developed a new […]
Bone Regeneration for Oral & Maxillofacial Applications

Bone Regeneration for Oral & Maxillofacial Applications

Bone is the world’s second-most transplanted tissue. Bone grafts are in high demand globally due to increasing prevalence of bone damage caused by ageing, diseases, and accidents. Bone grafts are also widely used by dental surgeons to restore bone in the oral-maxillofacial region, such as alveolar ridge augmentation for dental implant installation, mandibular reconstruction after […]
The Role of Cord Blood in Cell Therapy

The Role of Cord Blood in Cell Therapy

Since the first successful cord blood transplant in 1988, cord blood has been studied extensively for treating haematological malignancies and disorders. There are currently more than 800,000 cord blood units available in public cord blood banks worldwide, in which only 5% are released for unrelated hematopoietic stem cell transplantation. However, as cellular products are in […]
Developing foetal Mesenchymal Stem Cells (fMSC) for therapies

Developing foetal Mesenchymal Stem Cells (fMSC) for therapies

Primitive foetal mesenchymal stem cells (fMSC) hold unique characteristics that differ from their adult counterparts.  They have a higher capacity to expand without senescence, and do not form tumours in xenograft models. In addition, they have an expanded repertoire for directed differentiation.  This lecture will delve into the translation journey of developing fMSC for pre- […]
Joint Preservation: Cells or Exosomes?

Joint Preservation: Cells or Exosomes?

Joint preservation is an area of intense research within the orthopaedic community. Osteoarthritis is a very common, progressive, and debilitating joint disease characterised by the degeneration of the osteochondral construct due to the inevitable processes of overuse (‘wear-and-tear’). Arthroplasty is an option only for certain joints in the event of severe osteoarthritis, with robust evidence […]
Cell Therapy for Liver Regeneration

Cell Therapy for Liver Regeneration

The liver is one of the few organs that has true regenerative capacity, and this serves as the basis for conducting liver transplants in live donors.  However, in cases with chronic liver injury, hepatocytes may become senescent which leads to cell loss and fibrosis. This can in turn cause liver cirrhosis, portal hypertension and oncogenesis. […]
Laminins in the Development of Cell Therapy for Heart, Eye and Skin Disease

Laminins in the Development of Cell Therapy for Heart, Eye and Skin Disease

Culturing human embryonic stem cells (hESC) leads to the generation of various hESC-derived cells after in vitro differentiation. Such cells could be used in regenerative medicine to treat damaged tissues such as heart infarction that are non-renewable, blindness due to loss of photoreceptors or Type 1 diabetes due to absence of islet cells. Prof Karl […]
Gene Modification Therapies for In Utero Treatment of Hereditary Disease

Gene Modification Therapies for In Utero Treatment of Hereditary Disease

This presentation will explore the concept of In Utero Therapy of genetic diseases, the concepts and potential benefits of a prenatal approach, and will describe the progress in the field using specific disease models, as well as limitations, potential complications and challenges to clinical translation.  
Cultured Epithelial Autografts: Clinical Applications and Optimising the Cell Culture System

Cultured Epithelial Autografts: Clinical Applications and Optimising the Cell Culture System

Considerable progress has been made in the culture of keratinocytes, making it possible to obtain a large number of cultured epithelial autograft (CEA) sheets from a small skin biopsy to cover extensive wound areas. Improvements in tissue engineering practices to deliver keratinocytes without compromising their regenerative or stem cell properties have also been described recently. […]
PROGRESS AND CHALLENGES IN RETINAL CELL THERAPY FOR VISION REGENERATION

PROGRESS AND CHALLENGES IN RETINAL CELL THERAPY FOR VISION REGENERATION

The vast majority of degenerative retinal diseases that cause poor vision and blindness are currently incurable. Stem cell therapy holds promise as a potential treatment for these conditions. A substantial body of pre-clinical research has illuminated mechanisms of neural repair in the mammalian retina including synaptic reconnection and intercellular cytoplasmic materials transfer. Building on those […]
INNATE IMMUNE CELLS IN CANCER IMMUNOTHERAPY

INNATE IMMUNE CELLS IN CANCER IMMUNOTHERAPY

Innate immune cells, such as innate lymphoid cells and γδ T-cells, are critical in establishing the tumour microenvironment, as well as initiating and regulating anti-tumour adaptive immune responses. Its direct cytotoxicity against tumour cells, which is independent of MHC presentation and regulatory functions, can be harnessed to combat cancer in the form of adoptive therapy. […]
CELL THERAPY IN MYELOMA

CELL THERAPY IN MYELOMA

Myeloma, also known as Multiple Myeloma, is a blood cancer of plasma cells. Join Dr Chandramouli Nagarajan, Senior Consultant Haematologist at the Singapore General Hospital, to review the current use of Chimeric Antigen Receptor (CAR) T-cell therapy in Myeloma and its results. Dr Chandramouli will also discuss the future role of CAR-T therapy during the […]
SIDE EFFECTS OF CAR-T TREATMENT AND MANAGEMENT

SIDE EFFECTS OF CAR-T TREATMENT AND MANAGEMENT

Chimeric Antigen Receptor (CAR) treatment has given hope to many patients who would otherwise succumb to their relapsed/refractory diseases. However, this new therapy is often associated with significant toxicities, leading to morbidities and even mortalities occasionally. This talk focuses on the common side effects of CAR-T therapy as well as the early recognition and management […]
CURRENT CHALLENGES IN THE TREATMENT OF RELAPSED/REFRACTORY MALIGNANT HAEMATOLOGICAL CONDITIONS

CURRENT CHALLENGES IN THE TREATMENT OF RELAPSED/REFRACTORY MALIGNANT HAEMATOLOGICAL CONDITIONS

Watch this webinar on the management of patients with relapsed and refractory malignancies and look at the growing role of precision and personalized medicine in the management of these patients. With a focus on the Singapore context, the talk highlighted the current challenges faced and how these have been addressed to optimise care for patients. […]
ROLE OF CURRENT STEM CELL THERAPY FOR MALIGNANT HAEMATOLOGY

ROLE OF CURRENT STEM CELL THERAPY FOR MALIGNANT HAEMATOLOGY

Recent research on the successful translation of stem cell therapies to patients have enriched the hope that such regenerative strategies may one day become a treatment for a wide range of vexing diseases.  In fact, an exponential advancement in clinical trials revolving around stem cell-based therapies have been observed over the past few years. To […]
Practical Considerations in Delivering CAR-T Cell Therapies in Singapore

Practical Considerations in Delivering CAR-T Cell Therapies in Singapore

Chimeric Antigen Receptor (CAR) T-cell therapy is changing the treatment landscape of haematological malignancies. As these treatments gain regulatory approvals and become an available option to patients meeting disease indications, administrative and logistical challenges in delivering CAR therapy outside of clinical trials have also emerged.  The success of CAR T-cell therapy has brought about much […]
Regenarative Medicine for Parkinson’s Disease

Regenarative Medicine for Parkinson’s Disease

Parkinson’s Disease (PD) is a neurodegenerative disease affecting millions of predominantly elderly individuals worldwide. Despite intensive efforts devoted to drug discovery, the disease remains incurable. Pathologically, PD is characterised by the loss of a rather selective population of dopamine-producing neurons in a circumscribed region of the brain, which makes cell-based therapy a feasible option. Proof-of-concept […]
CAR-T Translational Opportunities In Paediatric Childhood Cancer

CAR-T Translational Opportunities In Paediatric Childhood Cancer

CAR-T therapy has changed the paradigm for the treatment of relapsed/refractory paediatric cancers who have otherwise exhausted all treatment options. However, the rapid translational success of cell therapy in B-lineage acute lymphoblastic leukaemia and lymphomas is not met with the same speed of translation in other paediatric childhood cancers. This talk will present an overview […]
CAR – Based Cell Therapies

CAR – Based Cell Therapies

The regulatory approval of genetically modified T cells in treating aggressive forms of cancers have garnered strong interest from the clinical, scientific and investment sectors to develop these advanced cell-based therapies for multiple diseases. An overview of CAR technology, recent ground-breaking pre-clinical and clinical studies, manufacturing innovations as well as regulatory roadmaps that are enabling […]
Cell Therapy: Promises and Challenges

Cell Therapy: Promises and Challenges

Cell therapy holds enormous promise for the treatment of diseases.  While the potential of cell therapy has been known for a while, the field has only started to expand in recent years. The use of CAR T-cell therapies to treat blood cancers in 2017 was a critical milestone in the field of cell therapy. Global investment […]